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Title: Chromone Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Penicillium erubescens KUFA0220 and Their Antibacterial Activity
Authors: Kumla, Decha
Pereira, José A.
Dethoup, Tida
Gales, Luis
Freitas-Silva, Joana
Costa, Paulo M.
Lee, Michael
Silva, Artur M.
Sekeroglu, Nazim
Pinto, Madalena M. M.
Kijjoa, Anake
First Published: 20-Aug-2018
Publisher: MDPI
Citation: Marine Drugs 2018, 16(8), 289.
Abstract: A previously unreported chromene derivative, 1-hydroxy-12-methoxycitromycin (1c), and four previously undescribed chromone derivatives, including pyanochromone (3b), spirofuranochromone (4), 7-hydroxy-6-methoxy-4-oxo-3-[(1E)-3-oxobut-1-en-1-yl]-4H-chromene-5-carboxylic acid (5), a pyranochromone dimer (6) were isolated, together with thirteen known compounds: β-sitostenone, ergosterol 5,8-endoperoxide, citromycin (1a), 12-methoxycitromycin (1b), myxotrichin D (1d), 12-methoxycitromycetin (1e), anhydrofulvic acid (2a), myxotrichin C (2b), penialidin D (2c), penialidin F (3a), SPF-3059-30 (7), GKK1032B (8) and secalonic acid A (9), from cultures of the marine sponge- associated fungus Penicillium erubescens KUFA0220. Compounds 1a–e, 2a, 3a, 4, 7–9, were tested for their antibacterial activity against Gram-positive and Gram-negative reference and multidrug-resistant strains isolated from the environment. Only 8 exhibited an in vitro growth inhibition of all Gram-positive bacteria whereas 9 showed growth inhibition of methicillin-resistant Staphyllococus aureus (MRSA). None of the compounds were active against Gram-negative bacteria tested.
DOI Link: 10.3390/md16080289
ISSN: 1660-3397
eISSN: 1660-3397
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2018. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description: The following are available online at 289/s1, Figure S1: Structures of β-sitosteanone and ergosterol-5,8-endoperoxide, isolated from the marine sponge-associated fungus Penicillium reubescens KUFA0220, Figures S2–S50 and S52–S53: 1D and 2D NMR spectra of isolated compounds, Figure S51: Ortep view of GKK1032B (8).
Appears in Collections:Published Articles, Dept. of Chemistry

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