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|Title:||Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks.|
Preston, Stephen G.
Nunn, Miles A.
Paesen, Guido C.
Austyn, Jonathan M.
Nuttall, Patricia A.
Lea, Susan M.
|Publisher:||Nature Research (part of Springer Nature)|
|Citation:||Scientific Reports, 2017, 7:16057|
|Abstract:||Two crystal structures of Japanin, an 18 kDa immune-modulatory lipocalin from the Brown Ear Tick (Rhipicephalus appendiculatus), have been determined at 2.2 and 2.4 Å resolution. In both crystal forms the protein is in complex with cholesterol, which sits in a closed pocket at the centre of the lipocalin barrel. Both crystal forms are dimers, which are also observed in solution. Molecular modelling suggests that previously-described members of a tick protein family bearing high sequence homology to Japanin are also likely to bind cholesterol or cholesterol derivatives.|
|Rights:||Copyright © the authors, 2017. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
|Description:||The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.|
|Appears in Collections:||Published Articles, Dept. of Molecular and Cell Biology|
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