Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/43254
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dc.contributor.authorCowen, T-
dc.contributor.authorKarim, K-
dc.contributor.authorPiletsky, SA-
dc.date.accessioned2019-02-07T09:45:55Z-
dc.date.issued2018-09-28-
dc.identifier.citationPOLYMER CHEMISTRY, 2018, 9 (36), pp. 4566-4573 (8)en
dc.identifier.issn1759-9954-
dc.identifier.urihttps://pubs.rsc.org/en/Content/ArticleLanding/2018/PY/C8PY00829A#!divAbstracten
dc.identifier.urihttp://hdl.handle.net/2381/43254-
dc.descriptionThe file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.en
dc.description.abstractThe solubility of polymer nanoparticles is a complex phenomenon dependent on solvent–solute and solute–solute interactions. Contrary to phase separation in standard polymerization reactions, which is a well established research area, the relationship between the solubility of polymer nanoparticles and the resulting diameter of the nanoparticles has been largely overlooked. Herein we demonstrate that the absolute size of polymer nanoparticles can be predicted (and controlled) by varying the relevant parameters of the polymerization conditions that influence the solubility and Flory parameter, χs, p. The position of the spinodal, associated with a given χs, p equivalent and determined with a simple thermodynamic model, allows an absolute value, Δχspinodal, to be applied in predicting polymer dimensions. The hydrodynamic diameter of particles at the primarily observed fraction was found to be dependent on D (nm) = −74Δχspinodal + 367 nm, where Δχspinodal must be positive for successful separation. Variation with total polymer fraction over a limited range can also be observed to follow a trend of approximately D (nm) = 173 ln[(xN)2 10−36/Δχspinodal] − 193 nm, thus giving a more general description of polymerization. We also assert the importance of separating spinodal-character phase separation from binodal-character phase separation in polymer nanoparticle synthesis. To the best of our knowledge this is the first successful Flory–Huggins based thermodynamic model of polymer nanoparticles, and should provide a useful guide to predictive design of future nanomaterialsen
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000445774500007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8c4e325952a993be76947405d4bce7d5-
dc.rightsCopyright © 2018, The Royal Society of Chemistry. Deposited with reference to the publisher’s open access archiving policy. (http://www.rioxx.net/licenses/all-rights-reserved)en
dc.subjectScience & Technologyen
dc.subjectPhysical Sciencesen
dc.subjectPolymer Scienceen
dc.subjectPRECIPITATION POLYMERIZATIONen
dc.subjectCELLULAR UPTAKEen
dc.subjectSILICA NANOPARTICLESen
dc.subjectDRUG-DELIVERYen
dc.subjectMOLAR VOLUMESen
dc.subjectPARTICLE-SIZEen
dc.subjectPARAMETERSen
dc.subjectMECHANISMen
dc.subjectDESIGNen
dc.subjectCELLSen
dc.titleSolubility and size of polymer nanoparticlesen
dc.typeJournal Articleen
dc.identifier.doi10.1039/c8py00829a-
dc.identifier.eissn1759-9962-
dc.description.statusPeer-revieweden
dc.description.versionPost-printen
dc.type.subtypeArticle;Journal-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF SCIENCE AND ENGINEERINGen
pubs.organisational-group/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistryen
dc.rights.embargodate2019-08-15-
dc.dateaccepted2018-08-13-
Appears in Collections:Published Articles, Dept. of Chemistry

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