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Title: Active intermixing of indirect and direct neurons builds the striatal mosaic
Authors: Tinterri, A
Menardy, F
Diana, M
Lokmane, L
Keita, M
Coulpier, F
Lemoine, S
Mailhes, C
Mathieu, B
Merchan-Sala, P
Campbell, K
Gyory, I
Grosschedl, R
Popa, D
Garel, S
First Published: 9-Nov-2018
Publisher: Nature Research (part of Springer Nature)
Citation: Nature Communications, 2018, 9, Article number: 4725
Abstract: The striatum controls behaviors via the activity of direct and indirect pathway projection neurons (dSPN and iSPN) that are intermingled in all compartments. While such cellular mosaic ensures the balanced activity of the two pathways, its developmental origin and pattern remains largely unknown. Here, we show that both SPN populations are specified embryonically and intermix progressively through multidirectional iSPN migration. Using conditional mutant mice, we found that inactivation of the dSPN-specific transcription factor Ebf1 impairs selective dSPN properties, including axon pathfinding, while molecular and functional features of iSPN were preserved. Ebf1 mutation disrupted iSPN/dSPN intermixing, resulting in an uneven distribution. Such architectural defect was selective of the matrix compartment, highlighting that intermixing is a parallel process to compartment formation. Our study reveals while iSPN/dSPN specification is largely independent, their intermingling emerges from an active migration of iSPN, thereby providing a novel framework for the building of striatal architecture.
DOI Link: 10.1038/s41467-018-07171-4
ISSN: 2041-1723
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2018. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description: Supplementary Information accompanies this paper at
Appears in Collections:Published Articles, Dept. of Molecular and Cell Biology

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