Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/43281
Title: Microsatellite variation of ESR1, ESR2, and AR in Serbian women with primary ovarian insufficiency
Authors: Li, J
Dalgleish, R
Vujovic, S
Dragojevic-Dikic, S
Ivanisevic, M
Ivovic, M
Tancic, M
Thompson, J
Al-Azzawi, F
First Published: 29-Aug-2018
Publisher: Taylor & Francis
Citation: Climacteric, 2018, 21 (5), pp. 472-477
Abstract: OBJECTIVE: This study aimed to investigate the potential role of microsatellite polymorphisms of the estrogen receptor alpha gene (ESR1) TA repeat, estrogen receptor beta gene (ESR2) CA repeat, and androgen receptor gene (AR) CAG and GGN repeats among Serbian women with primary ovarian insufficiency (POI). These microsatellites have been reported to be associated with POI in different racial/ethnic populations. METHODS: A cohort of 196 POI cases matched with 544 fertile controls was recruited by the Institute for Endocrinology, Diabetes and Metabolic Disorders of Serbia between 2007 and 2010. DNA was extracted from saliva. The four microsatellites were genotyped using a PCR-based assay to determine the repeat lengths. RESULTS: POI patients carried shorter repeat lengths of ESR2 (CA)n than controls (P = 0.034), but the difference was small. ESR1 (TA)n was on the borderline of statistical differences between groups (P = 0.059). AR (CAG)n and (GGN)n showed no association with POI. CONCLUSIONS: We cautiously conclude that microsatellite polymorphisms of gonadal steroid receptor genes might contribute to the genetic basis of POI in Serbian women, but a larger-scale study and family-based studies are warranted to validate our findings even though the sample size in this study is larger than any previously published in this field.
DOI Link: 10.1080/13697137.2018.1476967
eISSN: 1473-0804
Links: https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1476967
http://hdl.handle.net/2381/43281
Embargo on file until: 29-Aug-2019
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2018, International Menopause Society. Deposited with reference to the publisher’s open access archiving policy. (http://www.rioxx.net/licenses/all-rights-reserved)
Description: The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Genetics

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