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Title: Transition-Metal-Free Synthesis of C3-Arylated Benzofurans from Benzothiophenes and Phenols
Authors: Yang, K
Pulis, A
Perry, GJP
Procter, DJ
First Published: 14-Nov-2018
Publisher: American Chemical Society
Citation: Organic Letters, 2019, 20 (23), pp. 7498-7503
Abstract: We report a transition-metal-free synthesis of benzofurans from benzothiophenes and phenols that exploits the unique reactivity of sulfoxides. Through a sequence involving an interrupted Pummerer reaction and [3,3] sigmatropic rearrangement, phenols can be combined with readily accessible yet synthetically unexplored benzothiophene S-oxides to provide C3-arylated benzofuran products. The products from this approach can undergo subsequent functionalization to gain access to a range of important benzofuran derivatives.
DOI Link: 10.1021/acs.orglett.8b03267
eISSN: 1523-7052
Embargo on file until: 14-Nov-2019
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2018 American Chemical Society. Deposited with reference to the publisher’s open access archiving policy. (
Description: The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Chemistry

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