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Title: Association of circulating osteocalcin with cardiovascular disease and intermediate cardiovascular phenotypes: systematic review and meta-analysis
Authors: Seidu, S
Kunutsor, SK
Davies, MJ
Khunti, K
First Published: 2019
Publisher: Hindawi Publishing Corporation
Citation: Disease Markers, 2019, In Press
Abstract: Background: Circulating osteocalcin (OC), a marker which is central in bone mineralization, may be involved in the atherosclerotic process and influence the risk of developing cardiovascular disease (CVD). Aims: We conducted a systematic review and meta-analysis of published observational evidence, to assess and quantify the associations of circulating OC (total, undercarboxylated, and carboxylated OC) with cardiovascular outcomes (clinical CVD endpoints and intermediate cardiovascular phenotypes). Methods: Relevant studies were identified in a literature search of MEDLINE, EMBASE, and reference lists of relevant studies to April 2018. Mean differences and risk ratios with 95% CIs were aggregated using random-effects models. Results: Thirty observational studies (prospective cohort, case-control, and cross-sectional) with data on 20,212 unique participants were eligible. The pooled risk ratio in a comparison of extreme fourths of total OC levels was 0.93 (95% CI 0.69, 1.25) for composite CVD. Circulatingtotal OC levels were significantly lower in patients with cardiovascular conditions compared with those without these conditions -3.08 ng/ml (95% CI -4.75, -1.40; p<0.001). Prospective and cross-sectional data showed significant inverse associations between total OC and traits such as aortic or coronary calcification, coronary atherosclerosis or calcification, carotid intima-media thickness, and plaque score. There was limited data on carboxylated and undercarboxylated OC, with no evidence of associations. Conclusion: Observational evidence generally supports inverse and independent associations of circulating total OC with risk of atherosclerotic outcomes and CVD endpoints; however, the data were mostly based on cross-sectional evaluations. Large-scale prospective data are needed.
ISSN: 0278-0240
eISSN: 1875-8630
Embargo on file until: 1-Jan-10000
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2019. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description: The file associated with this record is under embargo until publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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