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Title: Drugs acting on the heart: antiarrhythmics
Authors: Hebbes, C
Thompson, JP
First Published: 28-May-2018
Publisher: Elsevier Masson for Medicine Publishing
Citation: ANAESTHESIA AND INTENSIVE CARE MEDICINE, 2018, 19 (7), pp. 370-374 (5)
Abstract: Arrhythmias are abnormalities of cardiac rate or rhythm occurring for a variety of reasons. They are common in the perioperative period and in intensive care. Causes may reflect an underlying heritable predisposition, the presence of new pathology either of the heart or conducting system, or as a result of systemic illness. Targets for antiarrhythmics include myocardial ion channels, muscarinic or nicotinic acetylcholine receptors, adrenergic or adenosine receptors. Arrhythmias may cause cardiac arrest and haemodynamic compromise, requiring rapid identification and corrective treatment either of rate or rhythm. Even where stable, arrhythmias present an increased risk of thromboembolic events requiring the use of anticoagulation. Treatment may be directed at controlling heart rate or rhythm to restore the circulation and tissue perfusion. Strategies may include prevention or correction of precipitating factors (such as electrolyte abnormalities or sepsis) and sometimes non-pharmacological treatments (cardioversion, surgical ablation or pacing). Antiarrhythmic drugs are often required. The targets, mechanisms and clinical guidelines are reviewed for common antiarrhythmic agents.
DOI Link: 10.1016/j.mpaic.2018.04.009
ISSN: 1472-0299
eISSN: 1878-7584
Embargo on file until: 28-May-2019
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2018 Elsevier Ltd. After an embargo period this version of the paper will be an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License (, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Description: The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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