Please use this identifier to cite or link to this item:
Title: High-Sensitivity Cardiac Troponin and New-Onset Heart Failure: Could a Quantitative Meta-Analysis Be Performed for the C Index?
Authors: Cao, TH
First Published: 1-Jun-2018
Publisher: Elsevier
Citation: JACC Heart Fail, 2018, 6 (6), pp. 540-541
Abstract: I have read the article by Evans and colleagues published in the JACC – Heart Failure with a great interest. The authors conducted a systematic review and meta-analysis of 67,063 patients with 4,165 incident heart failure events from 16 prospective studies. The results in this study suggest that serum high-sensitivity cardiac Troponin is strongly associated with the risk for incident heart failure beyond conventional risk factors. Certainly, Evans et al. have conducted a very valuable and exciting study. However, the authors mentioned that they were not able to perform a quantitative meta-analysis of the C index data in this study because some studies did not report confidence intervals (CI) for C indexes and their changes. Could the authors calculate a quantitative meta-analysis of the C index only using fully reported studies? This would provide a clearer view that many readers might be interested.
DOI Link: 10.1016/j.jchf.2018.03.007
eISSN: 2213-1787
Embargo on file until: 1-Jun-2019
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2018 by the American College of Cardiology Foundation. After an embargo period this version of the paper will be an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License (, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Description: The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

Files in This Item:
File Description SizeFormat 
High-Sensitivity+Cardiac+Troponin+and+New-Onset+Heart+Failure+_+JACC+Heart+Failure.pdfPost-review (final submitted author manuscript)259.8 kBAdobe PDFView/Open

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.