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Title: Relation of Aortic Stiffness to Left Ventricular Remodeling in Younger Adults With Type 2 Diabetes
Authors: Gulsin, GS
Swarbrick, DJ
Hunt, WH
Levelt, E
Graham-Brown, MPM
Parke, KS
Wormleighton, JV
Lai, FY
Yates, T
Wilmot, EG
Webb, DR
Davies, MJ
McCann, GP
First Published: Jul-2018
Publisher: American Diabetes Association
Citation: Diabetes, 2018, 67 (7), pp. 1395-1400
Abstract: Individuals with type 2 diabetes have a three- to fivefold increased risk of developing heart failure. Diabetic cardiomyopathy is typified by left ventricular (LV) concentric remodeling, which is a recognized predictor of adverse cardiovascular events. Although the mechanisms underlying LV remodeling in type 2 diabetes are unclear, progressive aortic stiffening may be a key determinant. The aim of this study was to assess the relationship between aortic stiffness and LV geometry in younger adults with type 2 diabetes, using multiparametric cardiovascular MRI. We prospectively recruited 80 adults (aged 18-65 years) with type 2 diabetes and no cardiovascular disease and 20 age- and sex-matched healthy control subjects. All subjects underwent comprehensive bio-anthropometric assessment and cardiac MRI, including measurement of aortic stiffness by aortic distensibility (AD). Type 2 diabetes was associated with increased LV mass, concentric LV remodeling, and lower AD compared with control subjects. On multivariable linear regression, AD was independently associated with concentric LV remodeling in type 2 diabetes. Aortic stiffness may therefore be a potential therapeutic target to prevent the development of heart failure in type 2 diabetes.
DOI Link: 10.2337/db18-0112
eISSN: 1939-327X
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2018 by the American Diabetes Association. Deposited with reference to the publisher’s open access archiving policy. (
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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