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Title: Conservation, divergence and functions of centromeric satellite DNA families in the Bovidae.
Authors: Escudeiro, A
Adega, F
Robinson, TJ
Heslop-Harrison, JS
Chaves, R
First Published: 19-Mar-2019
Publisher: Oxford University Press (OUP) for Society for Molecular Biology and Evolution
Citation: Genome Biology and Evolution, 2019, 11(4), pp. 1152–1165
Abstract: Repetitive satellite DNA (satDNA) sequences are abundant in eukaryote genomes, with a structural and functional role in centromeric function. We analysed the nucleotide sequence and chromosomal location of the five known cattle (Bos taurus) satDNA families in seven species from the tribe Tragelaphini (Bovinae subfamily). One of the families (SAT1.723) was present at the chromosomes' centromeres of the Tragelaphini species, as well in two more distantly related bovid species, Ovis aries and Capra hircus. Analysis of the interaction of SAT1.723 with centromeric proteins revealed that this satDNA sequence is involved in the centromeric activity in all the species analysed and that it is preserved for at least 15-20 My across Bovidae species. The satDNA sequence similarity among the analysed species reflected different stages of homogeneity/heterogeneity, revealing the evolutionary history of each satDNA family. The SAT1.723 monomer-flanking regions showed the presence of transposable elements, explaining the extensive shuffling of this satDNA between different genomic regions.
DOI Link: 10.1093/gbe/evz061
eISSN: 1759-6653
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2019. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-commercial License (, which permits unrestricted use, distribution, and reproduction in any medium non-commercially, provided the original author and source are credited.
Description: Supplementary data are available at Genome Biology and Evolution online. This project data have been deposited at GenBank (NCBI) under the acession numbers MK499473 to MK499615.
Appears in Collections:Published Articles, Dept. of Genetics

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