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dc.contributor.authorMcCutcheon, James E.-
dc.contributor.authorRoitman, Mitchell F.-
dc.identifier.citationACS Chemical Neuroscience, 2019, 10 (4), pp 1900–1907en
dc.descriptionThe file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.en
dc.description.abstractIn studies of appetitive Pavlovian conditioning, rewards are often delivered to subjects in a manner that confounds several processes. For example, delivery of a sugar pellet to a rodent requires movement to collect the pellet and is associated with sensory stimuli such as the sight and sound of the pellet arrival. Thus, any neurochemical events occurring in proximity to the reward may be related to multiple coincident phenomena. We used fast-scan cyclic voltammetry in rats to compare nucleus accumbens dopamine responses to two different modes of delivery: sucrose pellets, which require goal-directed action for their collection and are associated with sensory stimuli, and intraoral infusions of sucrose, which are passively received and not associated with external stimuli. We found that when rewards were unpredicted, both pellets and infusions evoked similar dopamine release. However, when rewards were predicted by distinct cues, greater dopamine release was evoked by pellet cues than infusion cues. Thus, dopamine responses to pellets, infusions as well as predictive cues suggest a nuanced role for dopamine in both reward seeking and reward evaluation.en
dc.description.sponsorshipThis work was supported by the National Institutes of Health [Grant Numbers K01-DA033380 (J.E.M.), R01-DA025634 (M.F.R.)]; and the University of Illinois at Chicago Campus Research Board (J.E.M.).en
dc.publisherAmerican Chemical Societyen
dc.rightsCopyright © 2018, American Chemical Society. Deposited with reference to the publisher’s open access archiving policy. (
dc.titleMode of Sucrose Delivery Alters Reward-Related Phasic Dopamine Signals in Nucleus Accumbensen
dc.typeJournal Articleen
pubs.organisational-group/Organisation/COLLEGE OF LIFE SCIENCESen
pubs.organisational-group/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciencesen
pubs.organisational-group/Organisation/COLLEGE OF LIFE SCIENCES/Biological Sciences/Neuroscience, Psychology and Behaviouren
Appears in Collections:Published Articles, Dept. of Neuroscience, Psychology and Behaviour

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