Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/44060
Title: Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation
Authors: Roques, M
Stanway, R
Rea, E
Markus, R
Brady, D
Anthony, H
Guttery, D
Tewari, R
First Published: 29-Jan-2019
Publisher: Company of Biologists
Citation: Biology Open, 2019, 8, bio036822
Abstract: Centrins are calmodulin-like phosphoproteins present in the centrosome and play an active role in the duplication, separation and organization of centrosomal structures such as the microtubule-organizing centre (MTOC) during mitosis. They are also major components of the basal body of flagella and cilia. In Plasmodium spp., the parasite that causes malaria, mitosis is closed during asexual replication and the MTOC is embedded within the intact nuclear membrane. The MTOC has been named the centriolar plaque and is similar to the spindle pole body in yeast. In all phases of asexual replication, repeated rounds of nuclear division precede cell division. However, our knowledge of the location and function of centrins during this process is limited. Previous studies have identified four putative centrins in the human parasite Plasmodium falciparum. We report here the cellular localization of an alveolate-specific centrin (PbCEN-4) during the atypical cell division of asexual replicative stages, using live cell imaging with the rodent malaria parasite P. berghei as a model system. We show that this centrin forms a multi-protein complex with other centrins, but is dispensable for parasite proliferation.
DOI Link: 10.1242/bio.036822
ISSN: 2046-6390
Links: http://bio.biologists.org/content/8/1/bio036822
http://hdl.handle.net/2381/44060
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2019. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description: Supplementary information available online at http://bio.biologists.org/lookup/doi/10.1242/bio.036822.supplemental
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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