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|Title:||Visual Dysfunction in Huntington's Disease: A Systematic Review.|
Hutchinson, Claire V.
|Citation:||Journal of Huntington's Disease, 2019, 8 (2), pp. 233-242|
|Abstract:||It is well-documented that patients with Huntington's disease (HD) exhibit specific deficits in visual cognition. A less well-documented literature also exists that suggests people with HD experience a number of disease-related changes to more rudimentary sensory visual processing. Here, we review evidence for the effects of HD on the integrity of the early visual pathways in humans along with changes to low-level visual sensitivity. We find evidence for reduced structural and functional integrity of the visual pathways, marked by retinal thinning, reduced VEP amplitude, and cell loss and thinning in visual cortex. We also find evidence of visual perceptual deficits, particularly for colour and motion. We suggest that future studies with well-defined HD and HD-related groups in appropriate numbers that systematically examine the relationship between structural changes to the visual system, basic visual perceptual deficits and disease stage/severity are therefore likely to yield promising results.|
|Rights:||Copyright © 2019, IOS Press. Deposited with reference to the publisher’s open access archiving policy. (http://www.rioxx.net/licenses/all-rights-reserved)|
|Appears in Collections:||Published Articles, Dept. of Neuroscience, Psychology and Behaviour|
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|HD+Vision+Review+Final+.pdf||Post-review (final submitted author manuscript)||548.88 kB||Adobe PDF||View/Open|
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