Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/44276
Title: Polypyridyl Zinc(II)-Indomethacin Complexes with Potent Anti-Breast Cancer Stem Cell Activity.
Authors: Rundstadler, Tiffany K.
Eskandari, Arvin
Norman, Sarah M.
Suntharalingam, Kogularamanan
First Published: 4-Sep-2018
Publisher: MDPI
Citation: Molecules, 2018, 23 (9), 2253
Abstract: Cancer stem cells (CSCs) are thought of as a clinically pertinent subpopulation of tumors, partly responsible for cancer relapse and metastasis. Research programs aimed at discovering anti-CSC agents have largely focused on biologics and purely organic molecules. Recently, we showed that a family of redox-active copper(II) complexes with phenanthroline-based ligands and nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin, are capable of potently and selectively killing breast CSCs. Herein we present analogous redox-inactive, zinc(II)-phenanthroline-indomethacin complexes with the ability to kill breast CSCs and bulk breast cancer cells with equal potency (in the submicro- or micromolar range). A single dose of the zinc(II) complexes could theoretically be administered to eliminate whole tumor populations. Excitingly, some of the zinc(II) complexes decrease the growth and viability of mammospheres to a comparable or higher degree than salinomycin, a compound known to effectively kill breast CSCs. As far as we are aware this is the first report to examine the anti-breast CSC activity of zinc(II)-containing compounds.
DOI Link: 10.3390/molecules23092253
eISSN: 1420-3049
Links: https://www.mdpi.com/1420-3049/23/9/2253
http://hdl.handle.net/2381/44276
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2018. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description: The following are available online, Figures S1–S9
Appears in Collections:Published Articles, Dept. of Chemistry

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