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Title: A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster.
Authors: Lu, C.
Laws, K.
Eskandari, A.
Suntharalingam, K.
First Published: 4-Sep-2017
Publisher: Royal Society of Chemistry
Citation: Dalton Transactions, 2017, 46 (38), pp. 12785-12789
Abstract: Tetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties, 1-4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevating the intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.
DOI Link: 10.1039/c7dt02789c
eISSN: 1477-9234
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2017, Royal Society of Chemistry. Deposited with reference to the publisher’s open access archiving policy. (
Appears in Collections:Published Articles, Dept. of Chemistry

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