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dc.contributor.authorLu, C.-
dc.contributor.authorLaws, K.-
dc.contributor.authorEskandari, A.-
dc.contributor.authorSuntharalingam, K.-
dc.identifier.citationDalton Transactions, 2017, 46 (38), pp. 12785-12789en
dc.description.abstractTetranuclear copper(ii) complexes containing multiple diclofenac and Schiff base moieties, 1-4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevating the intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.en
dc.description.sponsorshipK. S. is supported by a Leverhulme Early Career Fellowship (ECF-2014-178). K. L. and A. E. are supported by a King's College London GTS-PhD Studentship and Faculty Graduate School International Studentship, respectively. C. L. thanks the National Natural Science Foundation of China (Grant No. 21401078) for financial support. We are grateful to Prof. Robert Weinberg (Whitehead Institute, MIT) for providing the cell lines used in this study.en
dc.publisherRoyal Society of Chemistryen
dc.rightsCopyright © 2017, Royal Society of Chemistry. Deposited with reference to the publisher’s open access archiving policy. (
dc.subjectCell Line, Tumoren
dc.subjectCell Survivalen
dc.subjectCoordination Complexesen
dc.subjectCrystallography, X-Rayen
dc.subjectCyclooxygenase 2en
dc.subjectFluorescent Dyesen
dc.subjectMolecular Conformationen
dc.subjectNeoplastic Stem Cellsen
dc.subjectReactive Oxygen Speciesen
dc.subjectSchiff Basesen
dc.titleA reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster.en
dc.typeJournal Articleen
dc.type.subtypeJournal Article-
pubs.organisational-group/Organisation/COLLEGE OF SCIENCE AND ENGINEERINGen
pubs.organisational-group/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistryen
Appears in Collections:Published Articles, Dept. of Chemistry

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