Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/44431
Title: Synthesis, characterization, and cytotoxic properties of mono- and di-nuclear cobalt(ii)-polypyridyl complexes.
Authors: Eskandari, A
Kundu, A
Lu, C
Ghosh, S
Suntharalingam, K
First Published: 16-Mar-2018
Publisher: Royal Society of Chemistry
Citation: Dalton Transactions, 2018, 47 (16), pp. 5755-5763
Abstract: We report the synthesis and characterisation of mono- and di-nuclear cobalt(ii) complexes (1-3) containing L1, a polypyridyl ligand with pyrazole moieties. DNA binding studies suggest that the mono-nuclear complex, 1, binds to DNA via the grooves prior to inducing oxidative DNA cleavage whereas the larger di-nuclear complexes, 2 and 3, bind to DNA via the grooves and through intercalation prior to inducing oxidative DNA cleavage. The cobalt(ii) complexes display micromolar potency towards U2OS (bone osteosarcoma), HepG2 (liver hepatocellular carcinoma), and GM05757 (normal human fibroblast) cells, comparable to clinically used platinum agents, cisplatin and carboplatin. The cellular mechanism of action studies show that the most effective cobalt(ii) complex, 2, enters U2OS cells, penetrates the nucleus, induces genomic DNA damage, and triggers caspase-dependent apoptosis in a p53-independent manner. This study highlights the potential of di-nuclear cobalt(ii) complexes as artificial oxidative metallonucleases and tangible cancer cell-potent agents.
DOI Link: 10.1039/c8dt00577j
eISSN: 1477-9234
Links: https://pubs.rsc.org/en/content/articlelanding/2018/DT/C8DT00577J#!divAbstract
http://hdl.handle.net/2381/44431
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2018, Royal Society of Chemistry. Deposited with reference to the publisher’s open access archiving policy. (http://www.rioxx.net/licenses/all-rights-reserved)
Description: Electronic supplementary information (ESI) available. CCDC 1815777 and 1815778. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8dt00577j
Appears in Collections:Published Articles, Dept. of Chemistry

Files in This Item:
File Description SizeFormat 
c8dt00577j.pdfPost-review (final submitted author manuscript)1.4 MBAdobe PDFView/Open


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.