Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/44431
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dc.contributor.authorEskandari, A-
dc.contributor.authorKundu, A-
dc.contributor.authorLu, C-
dc.contributor.authorGhosh, S-
dc.contributor.authorSuntharalingam, K-
dc.date.accessioned2019-06-14T14:52:03Z-
dc.date.available2019-06-14T14:52:03Z-
dc.date.issued2018-03-16-
dc.identifier.citationDalton Transactions, 2018, 47 (16), pp. 5755-5763en
dc.identifier.urihttps://pubs.rsc.org/en/content/articlelanding/2018/DT/C8DT00577J#!divAbstracten
dc.identifier.urihttp://hdl.handle.net/2381/44431-
dc.descriptionElectronic supplementary information (ESI) available. CCDC 1815777 and 1815778. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8dt00577jen
dc.description.abstractWe report the synthesis and characterisation of mono- and di-nuclear cobalt(ii) complexes (1-3) containing L1, a polypyridyl ligand with pyrazole moieties. DNA binding studies suggest that the mono-nuclear complex, 1, binds to DNA via the grooves prior to inducing oxidative DNA cleavage whereas the larger di-nuclear complexes, 2 and 3, bind to DNA via the grooves and through intercalation prior to inducing oxidative DNA cleavage. The cobalt(ii) complexes display micromolar potency towards U2OS (bone osteosarcoma), HepG2 (liver hepatocellular carcinoma), and GM05757 (normal human fibroblast) cells, comparable to clinically used platinum agents, cisplatin and carboplatin. The cellular mechanism of action studies show that the most effective cobalt(ii) complex, 2, enters U2OS cells, penetrates the nucleus, induces genomic DNA damage, and triggers caspase-dependent apoptosis in a p53-independent manner. This study highlights the potential of di-nuclear cobalt(ii) complexes as artificial oxidative metallonucleases and tangible cancer cell-potent agents.en
dc.description.sponsorshipK. S. is supported by a Leverhulme Early Career Fellowship (ECF-2014-178). S. G. is funded by a UGC start-up grant (F.4-5/ 2006, BSR) and a Newton International Fellowship (AL130005/ 3). A. E. is supported by a King’s College London Faculty Graduate School International Studentship. C. L. thanks the Opening Project of Guangxi Colleges and Universities Key Laboratory of Beibu Gulf Oil and Natural Gas Resource Effective Utilization (2016KL0G08) for funding.en
dc.language.isoenen
dc.publisherRoyal Society of Chemistryen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/29634060-
dc.rightsCopyright © 2018, Royal Society of Chemistry. Deposited with reference to the publisher’s open access archiving policy. (http://www.rioxx.net/licenses/all-rights-reserved)en
dc.titleSynthesis, characterization, and cytotoxic properties of mono- and di-nuclear cobalt(ii)-polypyridyl complexes.en
dc.typeJournal Articleen
dc.identifier.doi10.1039/c8dt00577j-
dc.identifier.eissn1477-9234-
dc.description.statusPeer-revieweden
dc.description.versionPost-printen
dc.type.subtypeJournal Article-
pubs.organisational-group/Organisationen
pubs.organisational-group/Organisation/COLLEGE OF SCIENCE AND ENGINEERINGen
pubs.organisational-group/Organisation/COLLEGE OF SCIENCE AND ENGINEERING/Department of Chemistryen
dc.dateaccepted2018-03-15-
Appears in Collections:Published Articles, Dept. of Chemistry

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