Please use this identifier to cite or link to this item:
Title: Assessing a small field of view hybrid gamma camera for perioperative iodine-125 seed localisation.
Authors: Ng, AH
Alqahtani, MS
Jambi, LK
Bugby, SL
Lees, JE
Perkins, AC
First Published: 24-Apr-2019
Publisher: British Institute of Radiology
Citation: British Journal of Radiology, 2019; 92: 20190020.
Abstract: OBJECTIVES:: To examine the imaging capability of a novel small field of view hybrid γ camera (HGC) using 125I seeds prior to surgical use. METHODS:: The imaging performance of the camera system was assessed quantitatively and qualitatively at different source depths, source to collimator distances (SCD), activity levels, acquisition times and source separations, utilising bespoke phantoms. RESULTS:: The system sensitivity and spatial resolution of the HGC for 125I were 0.41 cps/MBq (at SCD 48 mm) and 1.53 ± 0.23 mm (at SCD 10 mm) respectively. The camera was able to detect the 125I seed at a SCD of 63 mm (with no scattering material in place) in images recorded within a one-minute acquisition time. The detection of the seeds beneath scattering material (simulating deep-seated tumours) was limited to depths of less than 20 mm beneath the skin surface with a SCD of 63  mm and seed activity of 2.43 MBq. Subjective assessments of the hybrid images acquired showed the capability of the HGC for localising the 125I seeds. CONCLUSION:: This preliminary ex vivo study demonstrates that the HGC is capable of detecting 125I seeds and could be a useful tool in radioactive seed localisation with the added benefit of providing hybrid optical γ images for guiding breast conserving surgery. ADVANCES IN KNOWLEDGE:: The SFOV HGC could provide high resolution fused optical-gamma images of 125I radioactive seeds indicating the potential use in intraoperative surgical procedure such as RSL.
DOI Link: 10.1259/bjr.20190020
eISSN: 1748-880X
Embargo on file until: 24-Apr-2020
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © 2019, British Institute of Radiology. Deposited with reference to the publisher’s open access archiving policy. (
Description: The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Physics and Astronomy

Files in This Item:
File Description SizeFormat 
bjr.20190020.pdfPublished (publisher PDF)1.14 MBAdobe PDFView/Open

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.