Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/44554
Title: Association of Chromosome 9p21 with Subsequent Coronary Heart Disease Events: A GENIUS-CHD Study of Individual Participant Data.
Authors: Patel, RS
Schmidt, AF
Tragante, V
McCubrey, RO
Holmes, MV
Howe, LJ
Direk, K
Åkerblom, A
Leander, K
Virani, SS
Kaminski, KA
Kuukasjärvi, P
Lee, V-V
Leiherer, A
Lenzini, PA
Levin, D
Lyytikäinen, L-P
Martinelli, N
Mons, U
Nelson, CP
Nikus, K
Drexel, H
Pilbrow, AP
Ploski, R
Sun, YV
Tanck, MWT
Tang, WHW
Trompet, S
van der Laan, SW
Van Setten, J
Vilmundarson, RO
Viviani Anselmi, C
Engert, JC
Vlachopoulou, E
Boerwinkle, E
Briguori, C
Carlquist, JF
Carruthers, KF
Casu, G
Deanfield, J
Deloukas, P
Dudbridge, F
Fitzpatrick, N
Fox, KAA
Gigante, B
James, S
Lokki, M-L
Lotufo, PA
Marziliano, N
Mordi, IR
Muhlestein, JB
Newton-Cheh, C
Pitha, J
Saely, CH
Girelli, D
Samman-Tahhan, A
Sandesara, PB
Teren, A
Timmis, A
Van de Werf, F
Wauters, E
Wilde, AAM
Ford, I
Stott, DJ
Algra, A
Hagström, E
Andreassi, MG
Ardissino, D
Arsenault, BJ
Ballantyne, CM
Bergmeijer, TO
Bezzina, CR
Body, SC
Bogaty, P
de Borst, GJ
Brenner, H
Hazen, SL
Burkhardt, R
Carpeggiani, C
Condorelli, G
Cooper-DeHoff, RM
Cresci, S
de Faire, U
Doughty, RN
Held, C
Hemingway, H
Hoefer, IE
Hovingh, GK
Muehlschlegel, JD
Johnson, JA
de Jong, PA
Jukema, JW
Kaczor, MP
Kähönen, M
Kettner, J
Kiliszek, M
Klungel, OH
Lagerqvist, B
Lambrechts, D
Dubé, M-P
Laurikka, JO
Lehtimäki, T
Lindholm, D
Mahmoodi, BK
Maitland-van der Zee, AH
McPherson, R
Melander, O
Metspalu, A
Pepinski, W
Olivieri, O
Allayee, H
Opolski, G
Palmer, CN
Pasterkamp, G
Pepine, CJ
Pereira, AC
Pilote, L
Quyyumi, AA
Richards, AM
Sanak, M
Scholz, M
Almgren, P
Siegbahn, A
Sinisalo, J
Smith, JG
Spertus, JA
Stewart, AFR
Szczeklik, W
Szpakowicz, A
Ten Berg, JM
Thanassoulis, G
Thiery, J
Alver, M
van der Graaf, Y
Visseren, FLJ
Waltenberger, J
Van der Harst, P
Tardif, J-C
Sattar, N
Lang, CC
Paré, G
Brophy, JM
Anderson, JL
Baranova, EV
März, W
Wallentin, L
Cameron, VA
Horne, BD
Samani, NJ
Hingorani, AD
Asselbergs, FW
Behlouli, H
Boeckx, B
Braund, PS
Breitling, LP
Delgado, G
Duarte, NE
Dufresne, L
Eriksson, N
Foco, L
Gijsberts, CM
Gong, Y
Hartiala, J
Heydarpour, M
Hubacek, JA
Kleber, M
Kofink, D
First Published: 21-Mar-2019
Publisher: American Heart Association, Lippincott, Williams & Wilkins
Citation: Circulation: Genomic and Precision Medicine, 2019, 12:e002471
Abstract: BACKGROUND: Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. METHODS: A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103,357 Europeans with established CHD at baseline from the GENIUS-CHD Consortium (73.1% male, mean age 62.9 years). The primary outcome, subsequent CHD death or myocardial infarction (CHD death/MI), occurred in 13,040 of the 93,115 participants with available outcome data. Effect estimates were compared to case/control risk obtained from CARDIoGRAMPlusC4D including 47,222 CHD cases and 122,264 controls free of CHD. RESULTS: Meta-analyses revealed no significant association between chromosome 9p21 and the primary outcome of CHD death/MI among those with established CHD at baseline (GENIUS-CHD OR 1.02; 95% CI 0.99-1.05). This contrasted with a strong association in CARDIoGRAMPlusC4D OR 1.20; 95% CI 1.18-1.22; p for interaction Conclusions: In contrast to studies comparing individuals with CHD to disease free controls, we found no clear association between genetic variation at chromosome 9p21 and risk of subsequent acute CHD events when all individuals had CHD at baseline. However, the association with subsequent revascularization may support the postulated mechanism of chromosome 9p21 for promoting atheroma development.
DOI Link: 10.1161/CIRCGEN.119.002471
eISSN: 2574-8300
Links: https://www.ahajournals.org/doi/10.1161/CIRCGEN.119.002471
http://hdl.handle.net/2381/44554
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2019. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description: The Data Supplement is available at https://www.ahajournals.org/doi/suppl/10.1161/CIRCGEN.119.002471.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

Files in This Item:
File Description SizeFormat 
CIRCGEN.119.002471.pdfPublished (publisher PDF)211.37 kBAdobe PDFView/Open


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.