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|Title:||ANAEMIA AND IRON DYSREGULATION - UNTAPPED THERAPEUTIC TARGETS IN CHRONIC LUNG DISEASE|
|Authors:||Patel, Mehul S|
Polkey, Michael I.
|Publisher:||BMJ Publishing Group|
|Citation:||BMJ Open Respiratory Research, 2019, In press|
|Abstract:||Hypoxia is common in many chronic lung diseases. Beyond pulmonary considerations, delivery of oxygen (O2) to the tissues and subsequent O2 utilisation is also determined by other factors including red blood cell mass and iron status; consequently disruption to these mechanisms provides further physiological strains on an already stressed system. O2 availability influences ventilation, regulates pulmonary blood flow and impacts gene expression throughout the body. Deleterious effects of poor tissue oxygenation include decreased exercise tolerance, increased cardiac strain and pulmonary hypertension in addition to pathophysiological involvement of multiple other organs resulting in progressive frailty. Increasing inspired O2 is expensive, disliked by patients and does not normalise tissue oxygenation; thus other strategies that improve O2 delivery and utilisation may provide a novel therapeutic opportunity in patients with lung disease. In this review, we focus on the rationale and possibilities for doing this by increasing haemoglobin availability or improving iron regulation.|
|Embargo on file until:||1-Jan-10000|
|Rights:||Copyright © the authors, 2019. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
|Description:||The file associated with this record is under embargo until publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.|
|Appears in Collections:||Published Articles, Dept. of Infection, Immunity and Inflammation|
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|final Submitted PDF mehul patel.pdf||Post-review (final submitted author manuscript)||704.55 kB||Adobe PDF||View/Open|
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