Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/45196
Title: Can we use short recordings for assessment of dynamic cerebral autoregulation? A sensitivity analysis study in acute ischaemic stroke and healthy subjects.
Authors: Intharakham, K
Panerai, RB
Katsogridakis, E
Lam, MY
Llwyd, O
Salinet, ASM
Nogueira, RC
Haunton, VJ
Robinson, TG
First Published: 8-Aug-2019
Publisher: IOP Publishing
Citation: Physiological Measurement, 2019
Abstract: Objective: It is unclear whether the duration of recordings influences estimates of dynamic cerebral autoregulation (dCA). Therefore, we performed a retrospective study of the effects of reducing recording durations on dCA estimates; with the potential to inform recording duration for reliable estimates in challenging clinical populations. Approach: Seventy-eight healthy control subjects and 79 acute ischaemic stroke (AIS) patients were included. Cerebral blood flow velocity was recorded with transcranial Doppler and continuous blood pressure with the Finapres device. The autoregulation index (ARI), derived with transfer function analysis, was calculated for recording durations at one-minute intervals between 1 and 5 minutes using the same starting point of each recording. Main results: Though recording duration did not affect the overall ARI value, when compared to control subjects, AIS patients had significantly lower ARI values for durations between 3 and 5 (p<0.0001), but not 1 and 2 minutes. The intraclass correlation coefficient of all participants, for reproducibility of the five recording durations, was 0.69. AIS patients classified as having impaired cerebral autoregulation (CA; ARI≤4) at 5 min, had a 7.1% rate of false negatives for both 4 and 3 min recordings, reaching 42.9% for 1 min recording. The percentage of false-positives also increased with reduced recording durations (from 0% at 5 to 16.2% at 1 minute). Significance: Reducing recording durations from 5 to 3 min can still provide reliable estimates of ARI, and may facilitate CA studies in potentially medically unstable AIS patients, as well as in other patient groups.
DOI Link: 10.1088/1361-6579/ab39d3
eISSN: 1361-6579
Links: https://iopscience.iop.org/article/10.1088/1361-6579/ab39d3
http://hdl.handle.net/2381/45196
Embargo on file until: 8-Aug-2020
Version: Post-print
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © IOP Publishing 2019. After an embargo period this version of the paper will be an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Description: The file associated with this record is under embargo until 12 months after publication, in accordance with the publisher's self-archiving policy. The full text may be available through the publisher links provided above.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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