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Title: An Investigation into the Inactivation Kinetics of Hydrogen Peroxide Vapor Against Clostridium difficile Endospores
Authors: Malik, D. J.
Shaw, C. M.
Shama, G.
Clokie, M. R. J.
Rielly, C. D.
First Published: 23-Aug-2016
Presented at: 19th Romanian International Conference on Chemistry and Chemical Engineering (RICCCE), Sibiu, ROMANIA
Start Date: 2-Sep-2015
End Date: 5-Sep-2015
Publisher: Taylor & Francis
Citation: Chemical Engineering Communications, 2016, 203 (12), pp. 1615-1624 (10)
Abstract: C. difficile spores are resistant to routine cleaning agents and are able to survive on inanimate surfaces for long periods of time. There is increasing evidence of the importance of the clinical environment as a reservoir for pathogenic agents and as a potential source of healthcare-associated infections (HCAIs). In this context, to reduce the risk of cross-transmission, terminal disinfection of hospital wards and isolation rooms using hydrogen peroxide vapor (HPV) is attracting attention. Spores of C. difficile (ribotype 027) were exposed to constant concentrations of HPV ranging between 11 and 92 mg m3 (ppm) for a range of exposure times in a specially designed chamber. The inactivation data thus obtained was fitted using the modified Chick–Watson inactivation model to obtain decimal reduction values (D values). D values ranged from 23 to 1.3 min at HPV concentrations of 11 and 92 ppm, respectively. We present a simple mathematical model based on the inactivation kinetic data obtained here to estimate the efficacy of commercial HPV processes used in healthcare environmental decontamination. C. difficile spores showed linear inactivation kinetics at steady HPV concentrations ranging between 10 and 90 ppm. The data obtained here was used to provide estimates of the inactivation efficacy of commercial HPV process cycles, which employ unsteady HPV concentrations during the decontamination process.
DOI Link: 10.1080/00986445.2016.1223058
ISSN: 0098-6445
eISSN: 1563-5201
Version: Publisher Version
Status: Peer-reviewed
Type: Conference Paper
Rights: Copyright © the authors, 2016. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License (, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Appears in Collections:Conference Papers & Presentations, Dept. of Infection, Immunity and Inflammation

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