Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/45539
Title: Planning, Implementing, and Running a Multicentre Preterm Birth Study with Biobank Resources in Brazil: The Preterm SAMBA Study
Authors: Souza, RT
Cecatti, JG
Costa, ML
Mayrink, J
Pacagnella, RC
Passini, R
Franchini, KG
Feitosa, FE
Calderon, IM
Rocha Filho, EA
Leite, DF
Vettorazzi, J
Kenny, LC
Baker, PN
Parpinelli, MA
Fernandes, KG
Guida, JP
Santana, D
Barbosa, RM
Galvao, RBF
Cassettari, BF
Pfitscher, L
de Feitosa, DL
First Published: 16-Jan-2019
Publisher: Hindawi
Citation: BioMed Research International Volume, 2019, Article ID 5476350, 8 pages
Abstract: Background. Our aim was to describe the steps in planning, implementing, and running a multicentre cohort study of maternal and perinatal health using a high-quality biobank comprised of maternal serum, plasma, and hair samples collected from five sites in Brazil. The Preterm SAMBA study, conducted by the Brazilian Network for Studies on Reproductive and Perinatal Health, was an innovative approach used to identify women at higher risk for preterm birth. It is also of great importance in the study of other maternal and perinatal complications in the context of Brazil, which is a middle-income country. Methods. We described phases of planning, implementing, and running the Preterm SAMBA study, a multicentre Brazilian cohort study of low-risk nulliparous pregnant women, to validate a set of metabolite biomarkers for preterm birth identified in an external cohort. Procedures and strategies used to plan, implement, and maintain this multicentre preterm birth study are described in detail. Barriers and experience cited in the current narrative are not usually discussed in the scientific literature or published study protocols. Results. Several barriers and strategies were identified in different phases of the Preterm SAMBA study at different levels of the study framework (steering committee; coordinating and local centres). Strategies implemented and resources used in the study are a legacy of the Brazilian Network, aimed at training collaborators in such complex settings. Conclusion. The Brazilian Network for Studies on Reproductive and Perinatal Health has gained some experience in conducting a multicentre cohort study using a resourceful biobank which may be helpful to other research groups and maternal/perinatal health networks that plan on employing a similar approach to a similar background.
DOI Link: 10.1155/2019/5476350
ISSN: 2314-6133
eISSN: 2314-6141
Links: https://www.hindawi.com/journals/bmri/2019/5476350/
http://hdl.handle.net/2381/45539
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2019. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description: The current manuscript describes several topics related to methodological aspect and the implementation of a multicentre cohort study and does not involve data to be available.
Appears in Collections:Published Articles, College of Medicine, Biological Sciences and Psychology

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