Please use this identifier to cite or link to this item:
Title: The Effectiveness and Cost-Effectiveness of Hepatitis C Screening for Migrants in the EU/EEA: A Systematic Review.
Authors: Greenaway, C
Makarenko, I
Chakra, CNA
Alabdulkarim, B
Christensen, R
Palayew, A
Tran, A
Staub, L
Pareek, M
Meerpohl, JJ
Noori, T
Veldhuijzen, I
Pottie, K
Castelli, F
Morton, RL
First Published: 14-Sep-2018
Publisher: MDPI
Citation: International Journal of Environmental Research and Public Health, 2018, 15(9), 2013;
Abstract: Chronic hepatitis C (HCV) is a public health priority in the European Union/European Economic Area (EU/EEA) and is a leading cause of chronic liver disease and liver cancer. Migrants account for a disproportionate number of HCV cases in the EU/EEA (mean 14% of cases and >50% of cases in some countries). We conducted two systematic reviews (SR) to estimate the effectiveness and cost-effectiveness of HCV screening for migrants living in the EU/EEA. We found that screening tests for HCV are highly sensitive and specific. Clinical trials report direct acting antiviral (DAA) therapies are well-tolerated in a wide range of populations and cure almost all cases (>95%) and lead to an 85% lower risk of developing hepatocellular carcinoma and an 80% lower risk of all-cause mortality. At 2015 costs, DAA based regimens were only moderately cost-effective and as a result less than 30% of people with HCV had been screened and less 5% of all HCV cases had been treated in the EU/EEA in 2015. Migrants face additional barriers in linkage to care and treatment due to several patient, practitioner, and health system barriers. Although decreasing HCV costs have made treatment more accessible in the EU/EEA, HCV elimination will only be possible in the region if health systems include and treat migrants for HCV.
DOI Link: 10.3390/ijerph15092013
eISSN: 1660-4601
Version: Publisher Version
Status: Peer-reviewed
Type: Journal Article
Rights: Copyright © the authors, 2018. This is an open-access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Description: The following are available online at s1, Figure S1: Analytic Framework for HCV Screening in Migrants; Table S1. Effectiveness and Cost-effectiveness Search Strategy; Tables S2–S5. Study profile GRADE; Table S6. Chronic HCV burden in migrants: the 10 migrant groups from intermediate/high HCV prevalence countries with the highest number of HCV cases in host EU/EEA countries.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

Files in This Item:
File Description SizeFormat 
The Effectiveness and Cost-Effectiveness of Hepatitis C Screening for Migrants in the EU/EEA: A Systematic Review.pdfPublished (publisher PDF)960.58 kBAdobe PDFView/Open

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.