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Title: Willingness of healthcare workers to accept voluntary stockpiled H5N1 vaccine in advance of pandemic activity
Authors: Pareek, Manish
Clark, Tristan
Dillon, Helen
Kumar, Rajesh
Stephenson, Iain
First Published: 18-Feb-2009
Publisher: Elsevier
Citation: Vaccine, 2009, 27 (8), pp. 1242-1247.
Abstract: Healthcare workers may be at risk during the next influenza pandemic. Priming with stockpiled vaccine may protect staff and reduce nosocomial transmission. Despite campaigns to increase seasonal influenza vaccine coverage, uptake among healthcare workers is generally low; creating uncertainty whether they would participate in pre-pandemic vaccine programmes. We conducted a cross-sectional questionnaire survey of healthcare workers in a UK hospital during, and 6 months after, a period of media reporting of an H5N1 outbreak at a commercial UK poultry farm. A total of 520 questionnaires were returned, representing 20% of frontline workforce. More respondents indicated willingness to accept stockpiled H5N1 vaccine during the period of media attention than after (166/262, 63.4% vs. 134/258, 51.9%; p = 0.009). Following multivariate analysis, factors associated with willingness to accept H5N1 vaccine included: previous seasonal vaccine (OR 6.2, 95% CI 3.0–12.8, p < 0.0001), awareness of occupational seasonal vaccine campaigns (OR 2.2, 95% CI 1.4–3.5, p = 0.001), belief that seasonal vaccine benefits themselves (OR 2.5, 95% CI 1.6–4.0, p < 0.0001) or the hospital (OR 3.6, 95% CI 2.3–5.8, p < 0.0001), belief that pandemic risk is high/moderate (OR 14.1, 95% CI 7.6–26.1, p < 0.0001) and would threaten healthcare workers (OR 2.9, 95% CI 1.8–4.5, p < 0.0001). Those who would not accept vaccine (220 respondents, 42.7%) if offered before the pandemic do not perceive pandemic influenza as a serious threat, and have concerns regarding vaccine safety. A majority of healthcare workers are amenable to accept stockpiled H5N1 vaccine if offered in advance of pandemic activity.
DOI Link: 10.1016/j.vaccine.2008.12.006
ISSN: 0264-410X
Type: Article
Rights: This is the author's final draft of the paper published as Vaccine, 2009, 27 (8), pp. 1242-1247. The final version is available from Doi: 10.1016/j.vaccine.2008.12.006
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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