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Title: Minisatellite MS32 Alleles Show Population Specificity Among Thai, Chinese, and Japanese
Authors: Yuan, Qing-Hua
Tanaka, Azusa
Kaszynski, Richard H.
Iino, Morio
Okuno, Tomoko
Tsuruyama, Tatsuaki
Yamamoto, Toshimichi
Jeffreys, Alec J.
Tamaki, Keiji
First Published: 22-Jan-2009
Publisher: Springer Verlag
Citation: Journal of Molecular Evolution, 2009, 68 (2), pp. 126-133.
Abstract: Lineages of structurally related alleles at minisatellite MS32 in human populations show considerable differentiation at the continental level. However, the regional specificity of these lineages remains unknown. We now describe the comparison of allele structures in Thai, Han Chinese, and Japanese populations with lineages previously established for North Europeans and Africans. The great majority of alignable Asian alleles showed their closest structural relative in Asia, with few instances of preferential alignment of Asian with European alleles and only one isolated incident showing a best match with an African allele. Further, there was a strong tendency, most marked for Japanese, for Asian alleles to align preferentially with other alleles from the same population, indicating strong regional specificity of allele lineages. This rapidly evolving minisatellite can therefore serve as a lineage marker for exploring recent events in human population history and dissecting population structure at the fine-scale level, as well as being an extremely informative DNA marker for personal identification.
DOI Link: 10.1007/s00239-008-9196-z
ISSN: 0022-2844
Type: Article
Description: This is the author's final draft of the paper published as Journal of Molecular Evolution, 2009, 68 (2), pp. 126-133. The original publication is available at Doi: 10.1007/s00239-008-9196-z
Appears in Collections:Published Articles, Dept. of Genetics

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