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Title: The tumor suppressor Pml regulates cell fate in the developing neocortex
Authors: Regad, Tarik
Bellodi, Cristian
Nicotera, Pierluigi
Salomoni, Paolo
First Published: Feb-2009
Publisher: Nature Publishing Group
Citation: Nature Neuroscience, 2009, 12 (2), pp. 132-140.
Abstract: The control of cell fate in neural progenitor cells is critical for nervous system development. Nevertheless, the processes involved are only partially known. We found that the expression of the tumor suppressor Pml was restricted to neural progenitor cells (NPCs) in the developing neocortex of the mouse. Notably, in Pml-/- cortices, the overall number of proliferating NPCs was increased and transition between the two major progenitor types, radial glial cells and basal progenitors, was impaired. This in turn resulted in reduced differentiation and an overall decrease in the thickness of the cortex wall. In NPCs, Pml regulated the subcellular distribution of the retinoblastoma protein (pRb) and the protein phosphatase 1, triggering pRb dephosphorylation. Together, these findings reveal an unexpected role of Pml in controlling the function of NPCs in the CNS.
DOI Link: 10.1038/nn.2251
ISSN: 1097-6256
Type: Article
Rights: This is the author's final draft of the paper published as Nature Neuroscience, 2009, 12 (2), pp. 132-140. The final version is available from Doi: 10.1038/nn.2251.
Appears in Collections:Published Articles, MRC Toxicology Unit

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