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Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/4823

Title: Genome-wide association study identifies eight loci associated with blood pressure
Authors: Newton-Cheh, Christopher
Johnson, Toby
Gateva, Vesela
Tobin, Martin D.
Bochud, Murielle
Coin, Lachlan
Najjar, Samar S.
Zhao, Jing Hua
Heath, Simon C.
Eyheramendy, Susana
Papadakis, Konstantinos
Meneton, Pierre
Wareham, Nicholas J.
Syvänen, Ann-Christine
Tanaka, Toshiko
Uda, Manuela
Jarvelin, Marjo-Riitta
Mooser, Vincent
Caulfield, Mark J.
Munroe, Patricia B.
Wallace, Chris
Jousilahti, Pekka
Chambers, John C.
Khaw, Kay-Tee
Mohlke, Karen L.
Newhouse, Stephen J.
Nilsson, Peter
van der Harst, Pim
Polidoro, Silvia
Song, Kijoung
Grobbee, Diederick E.
Onland-Moret, N. Charlotte
Perola, Markus
Bots, Michiel L.
Wain, Louise V.
Elliott, Katherine S.
Teumer, Alexander
Samani, Nilesh J.
Stringham, Heather M.
Luan, Jian'an
Lucas, Gavin
Kuusisto, Johanna
Burton, Paul R.
Zhang, Feng
Vollenweider, Peter
Hadley, David
McArdle, Wendy L.
Wellcome Trust Case Control Consortium
Webster, John
Zeggini, Eleftheria
Waeber, Gerard
Waterworth, Dawn M.
Yuan, Xin
de Jong, Paul E.
Boehnke, Michael
Groop, Leif
Orho-Melander, Marju
Peden, John F.
Valle, Timo T.
Allione, Alessandra
Di Gregorio, Alessandra
Guarrera, Simonetta
Panico, Salvatore
Ricceri, Fulvio
Romanazzi, Valeria
Bonnycastle, Lori L.
Snieder, Harold
Sacerdote, Carlotta
Vineis, Paolo
Barroso, Inês
Sandhu, Manjinder S.
Willer, Cristen J.
Seedorf, Udo
Luben, Robert N.
Crawford, Gabriel J.
Collins, Francis S.
Jackson, Anne U.
Bergman, Richard N.
Morken, Mario A.
Döring, Angela
Deloukas, Panos
Gieger, Christian
Illig, Thomas
Elosua, Roberto
van Gilst, Wiek H.
Meitinger, Thomas
Org, Elin
Pfeufer, Arne
Tognoni, Giovanni
Wichmann, H.-Erich
Kathiresan, Sekar
Soranzo, Nicole
Marrugat, Jaume
O'Donnell, Christopher J.
Schwartz, Stephen M.
Siscovick, David S.
Clarke, Robert
Forouhi, Nita G.
Subirana, Isaac
Freimer, Nelson B.
Hartikainen, Anna-Liisa
McCarthy, Mark I.
Lim, Noha
Lakatta, Edward G.
O'Reilly, Paul F.
Peltonen, Leena
Pouta, Anneli
Goel, Anuj
Hamsten, Anders
Sanna, Serena
Scheet, Paul
Schlessinger, David
Melander, Olle
Williams, Frances M.
Scuteri, Angelo
Dörr, Marcus
Voight, Benjamin F.
Völzke, Henry
Ernst, Florian
Felix, Stephan B.
Homuth, Georg
Lorbeer, Roberto
Reffelmann, Thorsten
Rettig, Rainer
Zhai, Guangju
Loos, Ruth J.F.
Völker, Uwe
Galan, Pilar
Gut, Ivo G.
Hercberg, Serge
Uiterwaal, Cuno S.
Scott, Laura J.
Lathrop, Mark
Zelenika, Diana
Salomaa, Veikko
Laakso, Markku
van der Schouw, Yvonne T.
Numans, Mattijs E.
Matullo, Giuseppe
Brown, Morris
Navis, Gerjan
Berglund, Göran
Beckmann, Jacques S.
Elliott, Paul
Bingham, Sheila A.
Kooner, Jaspal S.
Connell, John M.
Farrall, Martin
Bandinelli, Stefania
Ferrucci, Luigi
Dominiczak, Anna
Watkins, Hugh
Spector, Tim D.
Tuomilehto, Jaakko
Altshuler, David
Abecasis, Gonçalo R.
Bergmann, Sven
Strachan, David P.
Laan, Maris
Issue Date: Jun-2009
Publisher: Nature Publishing Group
Citation: Nature Genetics, 2009, 41 (6), pp. 666-676.
Abstract: Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10-24), CYP1A2 (P = 1 x 10-23), FGF5 (P = 1 x 10-21), SH2B3 (P = 3 x 10-18), MTHFR (P = 2 x 10-13), c10orf107 (P = 1 x 10-9), ZNF652 (P = 5 x 10-9) and PLCD3 (P = 1 x 10-8) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
ISSN: 1061-4036
Links: http://dx.doi.org/10.1038/ng.361
http://hdl.handle.net/2381/4823
Type: Article
Description: This paper was published as Nature Genetics, 2009, 41 (6), pp. 666-676. It is available from http://www.nature.com/ng/journal/v41/n6/abs/ng.361.html. Doi: 10.1038/ng.361
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Appears in Collections:Published Articles, Dept. of Health Sciences

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