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Title: Mammalian RGS proteins: Multifunctional regulators of cellular signalling
Authors: Willars, Gary B.
First Published: Jun-2006
Publisher: Elsevier
Citation: Seminars in Cell & Developmental Biology, 2006, 17 (3), pp. 363-376.
Abstract: Regulators of G-protein signalling (RGS) proteins are a large and diverse family initially identified as GTPase activating proteins (GAPs) of heterotrimeric G-protein Gα-subunits. At least some can also influence Gα activity through either effector antagonism or by acting as guanine nucleotide dissociation inhibitors (GDIs). As our understanding of RGS protein structure and function has developed, so has the realisation that they play roles beyond G-protein regulation. Such diversity of function is enabled by the variety of RGS protein structure and their ability to interact with other cellular molecules including phospholipids, receptors, effectors and scaffolds. The activity, sub-cellular distribution and expression levels of RGS proteins are dynamically regulated, providing a layer of complexity that has yet to be fully elucidated.
ISSN: 1084-9521
Type: Article
Description: This paper was published as Seminars in Cell & Developmental Biology, 2006, 17 (3), pp. 363-376. It is available from Doi: 10.1016/j.semcdb.2006.03.005
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Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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