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Title: Can cutaneous telangiectasiae as late normal-tissue injury predict cardiovascular disease in women receiving radiotherapy for breast cancer?
Authors: Tanteles, G. A.
Whitworth, J.
Mills, J.
Peat, I.
Osman, A.
McCann, G. P.
Chan, S.
Barwell, Julian G.
Talbot, Christopher J.
Symonds, R. P.
First Published: Jul-2009
Publisher: Nature Publishing Group
Citation: British Journal of Cancer, 2009, 101 (3), pp. 403-409.
Abstract: Background: Overall, ~5% of patients show late normal-tissue damage after radiotherapy with a smaller number having a risk of radiation-induced heart disease. Although the data are conflicting, large studies have shown increased risks of cardiovascular disease (CVD) for irradiated patients compared with non-irradiated ones, or for those treated to the left breast or chest wall compared with those treated to the right. Cutaneous telangiectasiae as late normal-tissue injury have so far only been regarded as a cosmetic burden. Methods: The relationship between late normal-tissue radiation injury phenotypes in 149 irradiated breast cancer patients and the presence of cardiovascular disease were examined. Results: A statistically significant association between the presence of skin telangiectasiae and the long-term risk of CVD was shown in these patients (P=0.017; Fisher's exact test). Interpretation: This association may represent initial evidence that telangiectasiae can be used as a marker of future radiation-induced cardiac complications. It could also suggest a common biological pathway for the development of both telangiectasiae and CVD on the basis of a genetically predisposed endothelium. To our knowledge this is the first reported study looking at this association.
DOI Link: 10.1038/sj.bjc.6605182
ISSN: 0007-0920
Type: Article
Rights: This is the author's final draft of the paper published as British Journal of Cancer, 2009, 101 (3), pp. 403-409. The final version is available from Doi: 10.1038/sj.bjc.6605182
Appears in Collections:Published Articles, Dept. of Genetics

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