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|Title:||Can cutaneous telangiectasiae as late normal-tissue injury predict cardiovascular disease in women receiving radiotherapy for breast cancer?|
|Authors:||Tanteles, G. A.|
McCann, G. P.
Barwell, Julian G.
Talbot, Christopher J.
Symonds, R. P.
|Publisher:||Nature Publishing Group|
|Citation:||British Journal of Cancer, 2009, 101 (3), pp. 403-409.|
|Abstract:||Background: Overall, ~5% of patients show late normal-tissue damage after radiotherapy with a smaller number having a risk of radiation-induced heart disease. Although the data are conflicting, large studies have shown increased risks of cardiovascular disease (CVD) for irradiated patients compared with non-irradiated ones, or for those treated to the left breast or chest wall compared with those treated to the right. Cutaneous telangiectasiae as late normal-tissue injury have so far only been regarded as a cosmetic burden. Methods: The relationship between late normal-tissue radiation injury phenotypes in 149 irradiated breast cancer patients and the presence of cardiovascular disease were examined. Results: A statistically significant association between the presence of skin telangiectasiae and the long-term risk of CVD was shown in these patients (P=0.017; Fisher's exact test). Interpretation: This association may represent initial evidence that telangiectasiae can be used as a marker of future radiation-induced cardiac complications. It could also suggest a common biological pathway for the development of both telangiectasiae and CVD on the basis of a genetically predisposed endothelium. To our knowledge this is the first reported study looking at this association.|
|Rights:||This is the author's final draft of the paper published as British Journal of Cancer, 2009, 101 (3), pp. 403-409. The final version is available from http://www.nature.com/bjc/journal/v101/n3/abs/6605182a.html. Doi: 10.1038/sj.bjc.6605182|
|Appears in Collections:||Published Articles, Dept. of Genetics|
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