Please use this identifier to cite or link to this item:
|Title:||Place preference induced by nucleus accumbens amphetamine is impaired by local blockade of Group II metabotropic glutamate receptors in rats|
|Authors:||Gerdjikov, Todor V.|
Beninger, Richard J.
|Citation:||BMC Neuroscience, 2006, 7(43)|
|Abstract:||Background: The nucleus accumbens (NAc) plays a critical role in amphetamine-produced conditioned place preference (CPP). In previous studies, NAc basal and amphetamine-produced DA transmission was altered by Group II mGluR agents. We tested whether NAc amphetamine CPP depends on Group II mGluR transmission. Results: NAc injections (0.5 μl/side) of the Group II mGluR antagonist (2 S)- a-ethylglutamic acid (EGLU: 0.01–0.8 μg but not 0.001 μg) impaired CPP. The drug did not block the acute locomotor effect of amphetamine. Conclusion: Results suggest that Group II mGluRs may be necessary for the establishment of NAc amphetamine-produced CPP. These receptors may also mediate other forms of reward-related learning dependent on this structure.|
|Rights:||This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.|
This is the final publisher edited version of the paper published as BMC Neuroscience, 2006, 7(43). This version was first published at http://www.biomedcentral.com/1471-2202/7/43, Doi: 10.1186/1471-2202-7-43.
|Appears in Collections:||Published Articles, School of Psychology|
Files in This Item:
|Gerdjikov & Beninger, 2006.pdf||705.25 kB||Adobe PDF||View/Open|
Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.