Please use this identifier to cite or link to this item:
Title: Place preference induced by nucleus accumbens amphetamine is impaired by local blockade of Group II metabotropic glutamate receptors in rats
Authors: Gerdjikov, Todor V.
Beninger, Richard J.
First Published: 30-May-2006
Publisher: BioMed Central
Citation: BMC Neuroscience, 2006, 7(43)
Abstract: Background: The nucleus accumbens (NAc) plays a critical role in amphetamine-produced conditioned place preference (CPP). In previous studies, NAc basal and amphetamine-produced DA transmission was altered by Group II mGluR agents. We tested whether NAc amphetamine CPP depends on Group II mGluR transmission. Results: NAc injections (0.5 μl/side) of the Group II mGluR antagonist (2 S)- a-ethylglutamic acid (EGLU: 0.01–0.8 μg but not 0.001 μg) impaired CPP. The drug did not block the acute locomotor effect of amphetamine. Conclusion: Results suggest that Group II mGluRs may be necessary for the establishment of NAc amphetamine-produced CPP. These receptors may also mediate other forms of reward-related learning dependent on this structure.
DOI Link: 10.1186/1471-2202-7-43
ISSN: 1471-2202
Type: Article
Rights: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This is the final publisher edited version of the paper published as BMC Neuroscience, 2006, 7(43). This version was first published at, Doi: 10.1186/1471-2202-7-43.
Appears in Collections:Published Articles, School of Psychology

Files in This Item:
File Description SizeFormat 
[01]Gerdjikov & Beninger, 2006.pdf705.25 kBAdobe PDFView/Open

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.