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Title: The phenotype and genotype experiment object model (PaGE-OM): a robust data structure for information related to DNA variation
Authors: Brookes, Anthony J.
Lehvaslaiho, Heikki
Muilu, Juha
Shigemoto, Yasumasa
Oroguchi, Takashige
Tomiki, Takeshi
Mukaiyama, Atsuhiro
Konagaya, Akihiko
Kojima, Toshio
Inoue, Ituro
Kuroda, Masako
Mizushima, Hiroshi
Thorisson, Gudmundur A.
Dash, Debasis
Rajeevan, Haseena
Darlison, Matthew W.
Woon, Mark
Fredman, David
Smith, Albert V.
Senger, Martin
Naito, Kimitoshi
Sugawara, Hideaki
First Published: 18-Mar-2009
Publisher: Wiley-Blackwell
Citation: Human Mutation, 2009, 30 (6), pp. 968-977
Abstract: Torrents of genotype–phenotype data are being generated, all of which must be captured, processed, integrated, and exploited. To do this optimally requires the use of standard and interoperable ‘‘object models,’’ providing a description of how to partition the total spectrum of information being dealt with into elemental ‘‘objects’’ (such as ‘‘alleles,’’ ‘‘genotypes,’’ ‘‘phenotype values,’’ ‘‘methods’’) with precisely stated logical interrelationships (such as ‘‘A objects are made up from one or more B objects’’). We herein propose the Phenotype and Genotype Experiment Object Model (PaGE-OM; www.pageom. org), which has been tested and implemented in conjunction with several major databases, and approved as a standard by the Object Management Group (OMG). PaGE-OM is open-source, ready for use by the wider community, and can be further developed as needs arise. It will help to improve information management, assist data integration, and simplify the task of informatics resource design and construction for genotype and phenotype data projects.
ISSN: 1059-7794
Type: Article
Description: Full text of this item is not currently available on the LRA. The definitive version is available at, Doi: 10.1002/humu.20973.
Appears in Collections:Published Articles, Dept. of Genetics

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