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Title: ß-defensins and Crohn's disease: confusion from counting copies
Authors: Hollox, Edward J.
First Published: 2009
Publisher: Nature Publishing Group
Citation: American Journal Gastroenterology, 2009, 105(2), pp.360–362
Abstract: Recent research has suggested that a family of antimicrobial and inflammatory molecules, called β-defensins, are involved in the etiology of Crohn's disease. In this issue, Bentley and colleagues provide data that disagree with previous studies. They show that the β-defensins that are copy number polymorphic have, on average, higher genomic copy number in patients when compared with healthy controls. This editorial places these new data in the context of previous research on the genetics of β-defensin copy number polymorphism and association with Crohn's disease. It also suggests a path allowing this research area to move forward with confidence.
DOI Link: 10.1038/ajg.2009.573
ISSN: 0002-9270
Type: Article
Rights: This is the author's final draft of the paper published as American Journal Gastroenterology, 2009, 105(2), pp.360–362 The final published version is available at doi:10.1038/ajg.2009.573.
Appears in Collections:Published Articles, Dept. of Genetics

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