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Title: The effects of Atm haploinsufficiency on mutation rate in the mouse germline and somatic tissue
Authors: Ahuja, Akshay K.
Barber, Ruth C.
Hardwick, Robert J.
Weil, Michael M.
Genik, Paula C.
Brenner, David J.
Dubrova, Yuri E.
First Published: 21-May-2008
Publisher: Oxford University Press
Citation: Mutagenesis, 2008, 23 (5), pp. 367-370
Abstract: Using single-molecule PCR, the frequency of spontaneous and radiation-induced mutation at an expanded simple tandem repeat (ESTR) locus was studied in DNA samples extracted from sperm and bone marrow of Atm knock-out (Atm+/-) heterozygous male mice. The frequency of spontaneous mutation in sperm and bone marrow in Atm+/- males did not significantly differ from that in wild-type BALB/c mice. Acute exposure to 1 Gy of γ-rays did not affect ESTR mutation frequency in bone marrow and resulted in similar increases in sperm samples taken from Atm+/- and BALB/c males. Taken together, these results suggest that the Atm haploinsufficiency analysed in our study does not affect spontaneous and radiation-induced ESTR mutation frequency in mice.
DOI Link: 10.1093/mutage/gen028
ISSN: 1464-3804
Type: Article
Rights: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Mutagenesis following peer review. The definitive publisher-authenticated version, Mutagenesis, 2008, 23 (5), pp. 367-370, is available online at: Doi: 10.1093/mutage/gen028
Appears in Collections:Published Articles, Dept. of Genetics

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