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Title: Immune complex formation in IgA nephropathy: a case of the ‘right’ antibodies in the ‘wrong’ place at the ‘wrong’ time?
Authors: Barratt, Jonathan
Eitner, Frank
Feehally, John
Floege, Jürgen
First Published: Dec-2009
Publisher: Oxford University Press (OUP)
Citation: Nephrology Dialysis Transplantation, 2009, 24 (12), pp. 3620-3623.
Abstract: One of the most striking findings in IgAN is an increase in the circulating levels of poorly galactosylated IgA1 O-glycoforms (Figure 1B). This has been observed in patient populations from North America, Europe and Asia, using a variety of techniques [1–3]. Importantly, two studies of IgA1 eluted from isolated glomeruli have shown that mesangial IgA is enriched with poorly galactosylated IgA1 O-glycoforms, strongly implicating the composition of IgA1 hinge region glycans in the mechanism of IgA1 deposition [4,5]. Novak and colleagues have also reported that these poorly galactosylated IgA1 O-glycoforms are predominantly found in circulating high molecular weight IgA-IC in IgAN [6].
DOI Link: 10.1093/ndt/gfp441
ISSN: 0931-0509
Type: Article
Rights: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Nephrology Dialysis Transplantation, 2009, 24 (12), pp. 3620-3623 following peer review. The definitive publisher-authenticated version is available online at: Doi: 10.1093/ndt/gfp441
Description: Comment on: Suzuki H, Fan R, Zhang Z, Brown R, Hall S, Julian BA, Chatham WW, Suzuki Y, Wyatt RJ, Moldoveanu Z, Lee JY, Robinson J, Tomana M, Tomino Y, Mestecky J, Novak J. Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity. J Clin Invest. 2009 Jun;119(6):1668-77. doi: 10.1172/JCI38468. Epub 2009 May 26
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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