Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/8166
Title: Dietary Chemopreventive Phytochemicals: Too Little or Too Much?
Authors: Moiseeva, Elena P.
Manson, Margaret M.
First Published: 1-Jul-2009
Publisher: American Association for Cancer Research
Citation: Cancer Prevention Research, 2009, 2 (7), pp. 611-616.
Abstract: There is a large body of evidence that the consumption of fruit and vegetables can decrease the risk of cancer. However, the link between diet and health is extremely complex. Some dietary phytochemicals seem to offer protection in an exposure-related manner and many molecular targets and signaling pathways affected by phytochemicals have been discovered. Although in vitro studies have contributed significantly to our understanding, quite a number use concentrations orders of magnitude greater than those achievable in humans or toxic to normal tissues (exemplified by toxic concentrations of indole-3-carbinol, epigallocatechin-3-gallate, curcumin, and genistein for breast cells). Such studies may produce results that are physiologically irrelevant, thus hindering predictions of efficacy. Here, we argue for careful consideration to be given to the in vitro experimental conditions under which dietary phytochemicals are investigated. Design features, such as the use of appropriate nontoxic concentrations, extended treatment times, three-dimensional cultures, primary tumor cultures, and comparison of susceptibility of various cancer subtypes, should improve our understanding of their molecular targets. This in turn would facilitate predictions as to their potential usefulness in the clinic.
DOI Link: 10.1158/1940-6207.CAPR-08-0102
ISSN: 1940-6207
Links: http://cancerpreventionresearch.aacrjournals.org/content/2/7/611
http://hdl.handle.net/2381/8166
Type: Article
Rights: This is the authors' final draft of the paper published as Cancer Prevention Research, 2009, 2 (7), pp. 611-616. The final version is available from http://cancerpreventionresearch.aacrjournals.org/cgi/content/abstract/2/7/611. Doi: 10.1158/1940-6207.CAPR-08-0102
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

Files in This Item:
File Description SizeFormat 
CaPR final.pdf166.11 kBAdobe PDFView/Open


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.