Leicester Research Archive

Leicester Research Archive >
College of Medicine, Biological Sciences and Psychology >
Genetics, Department of >
Published Articles, Dept. of Genetics >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/829

Title: The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline
Authors: Burr, Karen L.A.
van Duyn-Goedhart, Annemarie
Hickenbotham, Peter
van Buul, Paul P.W.
Dubrova, Yuri E.
Issue Date: 1-Apr-2007
Publisher: Elsevier
Citation: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis, 2007, 617 (1-2), pp.147-151.
Abstract: Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of mismatch repair deficient Msh2 knock-out mice. Spontaneous mutation rates in homozygous Msh2-/- males were significantly higher than those in isogenic wild-type (Msh2+/+) and heterozygous (Msh2+/-) mice. In contrast, the irradiated Msh2-/- mice did not show any detectable increases in their mutation rate, whereas significant ESTR mutation induction was observed in the irradiated Msh2+/+ and Msh2+/- animals. Considering these data and the results of other publications, we propose that the Msh2-deficient mice possess a mutator phenotype in their germline and somatic tissues while the loss of a single Msh2 allele does not affect the stability of heterozygotes.
Links: http://hdl.handle.net/2381/829
Type: Article
Description: This is the author's draft of an article published by Elsevier http://www.elsevier.com/wps/find/journaldescription.cws_home/506092/description#description
Appears in Collections:Published Articles, Dept. of Genetics

Files in This Item:

File Description SizeFormat
Msh2 Leiden revised 2.pdf172.85 kBAdobe PDFView/Open
View Statistics

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

MAINTAINER