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Title: The Effects of Heliox on the Output and Particle-Size Distribution of Salbutamol Using Jet and Vibrating Mesh Nebulizers
Authors: O'Callaghan, Christopher L.
White, Judy A.
Jackson, Judith
Crosby, David
Dougill, Beatriz
Bland, Hubert
First Published: 25-Dec-2007
Publisher: Mary Ann Liebert, Inc. publishers
Citation: Journal Of Aerosol Medicine, 2007, 20(4), pp.434-444.
Abstract: There are theoretical benefits of delivering drug aerosols to patients with asthma and chronic obstructive pulmonary disease (COPD) using Heliox as a carrier gas. The objective of this study was to develop systems to allow bronchodilators nebulized by a breath enhanced jet nebulizer and a vibrating mesh nebulizer to be delivered to patients in Heliox. This was achieved by attaching a reservoir to the nebulizers to ensure inhaled Heliox was not diluted by entrained air. For the vibrating mesh nebulizer, the total output was significantly higher after 5 min of nebulization when Heliox rather than air was used as the delivery gas (p < 0.001). The proportion of drug in particles <5 μm was 58.1% for Heliox and 50.1% when air was entrained. When the breath enhanced nebulizer was used a much higher driving flow of Heliox, compared to air, was required to deliver a similar dose of drug (p < 0.05). The total amount of drug likely to be inhaled was significantly higher when the vibrating mesh nebulizer (Aerogen) was used compared to the breath enhanced jet nebulizer (Pari LC plus) (p < 0.001). The amount of drug likely to be inhaled was also significantly greater for the adult as opposed to pediatric breathing pattern for all nebulizers and flows tested with the exception of the Aeroneb and Heliox entrainment. In this case, total amounts were similar for both patterns but for the pediatric pattern, the time taken to reach this output was longer. Such information is required to allow appropriate interpretation of clinical trials of drug delivery using Heliox.
DOI Link: 10.1089/jam.2007.0614
ISSN: 0894-2684
Version: Post-print
Status: Peer-reviewed
Type: Article
Description: This is an author's final draft version of an article published in the Journal Of Aerosol Medicine. Copyright © 2007 Mary Ann Liebert, Inc.; Journal Of Aerosol Medicine is available online at:
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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