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Title: Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad
Authors: Lim, Kah Wai
Alberti, Patrizia
Guédin, Aurore
Lacroix, Laurent
Riou, Jean-François
Royle, Nicola J.
Mergny, Jean-Louis
Phan, Anh Tuân
First Published: Oct-2009
Publisher: Oxford University Press (OUP)
Citation: Nucleic Acids Research, 2009, 37 (18), pp. 6239-6248.
Abstract: Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four human telomeric variant CTAGGG repeats in potassium solution. Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G·C base pair and a G·C·G·C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA.
DOI Link: 10.1093/nar/gkp630
ISSN: 0305-1048
Type: Article
Rights: This paper was published as Nucleic Acids Research, 2009, 37 (18), pp. 6239-6248. It is also available from Doi: 10.1093/nar/gkp630
Appears in Collections:Published Articles, Dept. of Genetics

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