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Title: SGS1 is required for telomere elongation in the absence of telomerase
Authors: Huang, Pei-Hsiu
Pryde, Fiona E.
Lester, Darren
Maddison, Rachelle L.
Borts, Rhona H.
Hickson, Ian D.
Louis, Edward J.
First Published: 23-Jan-2001
Publisher: Elsevier (Cell Press)
Citation: Current biology, 2001, 11(2), pp.125-129.
Abstract: In S. cerevisiae, mutations in genes that encode telomerase components, such as the genes EST1, EST2, EST3, and TLC1, result in the loss of telomerase activity in vivo [1-3]. Two telomerase-independent mechanisms can overcome the resulting senescence. Type I survival is characterized by amplification of the subtelomeric Y' elements with a short telomere repeat tract at the terminus [4]. Type II survivors arise through the abrupt addition of long tracts of telomere repeats [4-6]. Both mechanisms are dependent on RAD52[4,5] and on either RAD50 or RAD51[6,7]. We show here that the telomere elongation pathway in yeast (type II) is dependent on SGS1, the yeast homolog of the gene products of Werner's (WRN) [8] and Bloom's (BLM) [9] syndromes. Survival in the absence of SGS1 and EST2 is dependent upon RAD52 and RAD51 but not RAD50. We propose that the RecQ family helicases are required for processing a DNA structure specific to eroding telomeres.
ISSN: 0960-9822
Type: Article
Description: The full-text of this item is currently not available on the LRA. The original published version can be found on the publisher's website at: doi:10.1016/S0960-9822(01)00021-5
Appears in Collections:Published Articles, Dept. of Genetics

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