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Title: Chemokine receptor expression in tumour islets and stroma in non-small cell lung cancer
Authors: Ohri, Chandra M.
Shikotra, Aarti
Green, Ruth H.
Waller, David A.
Bradding, Peter
First Published: 29-Apr-2010
Publisher: BioMed Central Ltd
Citation: BMC Cancer, 2010, 10:172
Abstract: Background: We have previously demonstrated that tumour islet infiltration by macrophages is associated with extended survival (ES) in NSCLC. We therefore hypothesised that patients with improved survival would have high tumour islet expression of chemokine receptors known to be associated with favourable prognosis in cancer. This study investigated chemokine receptor expression in the tumour islets and stroma in NSCLC. Methods: We used immunohistochemistry to identify cells expressing CXCR1, CXCR2, CXCR3, CXCR4, CXCR5 and CCR1 in the tumour islets and stroma in 20 patients with surgically resected NSCLC. Correlations were made with macrophage and mast cell expression. Results: There was increased expression of CXCR2, CXCR3, and CCR1 in the tumour islets of ES compared with poor survival (PS) patients (p = 0.007, 0.01, and 0.002, respectively). There was an association between 5 year survival and tumour islet CXCR2, CXCR3 and CCR1 density (p = 0.02, 0.003 and <0.001, respectively) as well as stromal CXCR3 density (p = 0.003). There was a positive correlation between macrophage density and CXCR3 expression (r[subscript s] = 0.520, p = 0.02) and between mast cell density and CXCR3 expression (r[subscript s] = 0.499, p = 0.03) in the tumour islets. Conclusion: Above median expression of CXCR2, CXCR3 and CCR1 in the tumour islets is associated with increased survival in NSCLC, and expression of CXCR3 correlates with increased macrophage and mast cell infiltration in the tumour islets.
DOI Link: 10.1186/1471-2407-10-172
eISSN: 1471-2407
Version: Publisher Version
Status: Peer-reviewed
Type: Published Article
Rights: Copyright © 2010 Ohri et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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