Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/8804
Title: Tumour necrosis factor-alpha expression in tumour islets confers a survival advantage in non-small cell lung cancer
Authors: Ohri, Chandra M.
Shikotra, Aarti
Green, Ruth H.
Waller, David A.
Bradding, Peter
First Published: 23-Jun-2010
Publisher: BioMed Central Ltd
Citation: BMC Cancer 2010, 10:323
Abstract: Background: The role of TNFα in cancer is complex with both pro-tumourigenic and anti-tumourigenic roles proposed. We hypothesised that anatomical microlocalisation is critical for its function. Methods: This study used immunohistochemistry to investigate the expression of TNFα in the tumour islets and stroma with respect to survival in 133 patients with surgically resected NSCLC. Results: TNFα expression was increased in the tumour islets of patients with above median survival (AMS) compared to those with below median survival (BMS)(p = 0.006), but similar in the stroma of both groups. Increasing tumour islet TNFα density was a favorable independent prognostic indicator (p = 0.048) while stromal TNFα density was an independent predictor of reduced survival (p = 0.007). Patients with high TNFα expression (upper tertile) had a significantly higher 5-year survival compared to patients in the lower tertile (43% versus 22%, p = 0.01). In patients with AMS, 100% of TNFα[superscript +] cells were macrophages and mast cells, compared to only 28% in the islets and 50% in the stroma of BMS patients (p < 0.001). Conclusions: The expression of TNFα in the tumour islets of patients with NSCLC is associated with improved survival suggesting a role in the host anti-tumour immunological response. The expression of TNFα by macrophages and mast cells is critical for this relationship.
DOI Link: 10.1186/1471-2407-10-323
eISSN: 1471-2407
Links: http://www.biomedcentral.com/1471-2407/10/323
http://hdl.handle.net/2381/8804
Version: Publisher Version
Status: Peer-reviewed
Type: Published Article
Rights: Copyright © 2010 Ohri et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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