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Title: The Molecular Interactions between Filtered Proteins and Proximal Tubular Cells in Proteinuria
Authors: Baines, Richard J.
Brunskill, Nigel J.
First Published: Nov-2008
Publisher: Karger
Citation: Nephron Experimental Nephrology, 2008, 110 (2), pp. E67-E71.
Abstract: Proteinuria is associated with progressive chronic kidney disease and poor cardiovascular outcomes. Exposure of proximal tubular epithelial cells to excess proteins leads to the development of proteinuric nephropathy with tubular atrophy, interstitial inflammation and scarring. Numerous signalling pathways are activated in proximal tubular epithelial cells under proteinuric conditions resulting in gene transcription, altered growth and the secretion of inflammatory and profibrotic mediators. Megalin, the proximal tubular scavenger receptor for filtered macromolecules, has intrinsic signalling functions and may also link albumin to growth factor receptor signalling via regulated intramembrane proteolysis. It now seems that endocytosis is not always a prerequisite for albumin-evoked alterations in proximal tubular cell phenotype. Recent evidence shows the presence of other potential receptors for proteins, such as the neonatal Fc receptor and CD36, in the proximal tubular epithelium.
DOI Link: 10.1159/000161982
ISSN: 1660-8151
Type: Article
Rights: This is the author's final draft of the paper published as Nephron Experimental Nephrology, 2008, 110 (2), pp. E67-E71. The final version is available from © 2008 S. Karger AG, Basel. Doi: 10.1159/000161982
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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