Leicester Research Archive

Leicester Research Archive >
College of Medicine, Biological Sciences and Psychology >
Genetics, Department of >
Books & Book Chapters, Dept. of Genetics >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/8938

Title: Interaction of Genetic and Environmental Factors in Saccharomyces cerevisiae Meiosis: The Devil is in the Details
Authors: Cotton, Victoria E.
Hoffmann, Eva R.
Abdullah, Mohammed F.F.
Borts, Rhona H.
Issue Date: 2009
Publisher: Springer
Citation: Cotton, Victoria E. et al., Interaction of Genetic and Environmental Factors in Saccharomyces cerevisiae Meiosis: The Devil is in the Details, In: Keeney, S., Meiosis, Volume 1, Molecular and Genetic Methods, Series: Methods in Molecular Biology, Vol. 557, Humana Press©2009.
Abstract: One of the most important principles of scientific endeavour is that the results be reproducible from lab to lab. Although research groups rarely redo the published experiments of their colleagues, research plans almost always rely on the work of someone else. The assumption is that if the same experiment were repeated in another lab, results would be so similar that the same interpretation would be favoured. This notion allows one researcher to compare his/her own results to earlier work from other labs. An essential prerequisite for this is that the experiments are done in identical conditions and therefore the methodology must be clearly stated. While this may be scientific common sense, adherence is difficult because “standard” methods vary from one laboratory to another in subtle ways that are often not reported. More importantly, for many years the field of yeast meiotic recombination considered typical differences to be innocuous. This chapter will highlight the documented environmental and genetic variables that are known to influence meiotic recombination in Saccharomyces cerevisiae. Other potential methodological sources of variation in meiotic experiments are also discussed. A careful assessment of the effects of these variables, has led to insights into our understanding of the control of recombination and meiosis.
Series/Report no.: Series: Methods in Molecular Biology
vol.557
ISBN: 978-1-934115-66-4
Links: http://dx.doi.org/10.1007/978-1-59745-527-5_1
http://www.springerlink.com/content/t36726451(...)
http://hdl.handle.net/2381/8938
Type: Book chapter
Description: The full text of this book chapter is not available on the LRA. http://www.springerlink.com/content/t36726451110787j/#section=607183&page=1&locus=0 , DOI:10.1007/978-1-59745-527-5_1
Appears in Collections:Books & Book Chapters, Dept. of Genetics

Files in This Item:

There are no files associated with this item.

View Statistics

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

MAINTAINER