Please use this identifier to cite or link to this item:
Title: Longitudinal Evaluation of Airway Function 21 Years after Preterm Birth
Authors: Narang, Indra
Rosenthal, Mark
Cremonesini, David
Silverman, Mike
Bush, Andrew
First Published: 17-Apr-2008
Publisher: American Thoracic Society
Citation: American Journal of Respiratory and Critical Care Medicine, 2008, 178 (1), pp. 74-80.
Abstract: Rationale: There are limited longitudinal data about respiratory morbidity and lung function after preterm birth into adulthood. Objectives: To determine the evolution of respiratory symptoms, spirometry, and airway hyperresponsiveness of ex-preterm subjects from childhood into adulthood. Methods: Ex-preterm subjects (median birth weight, 1,440 g; median gestation, 31.5 wk), recruited at birth (not treated with surfactant), had excess respiratory symptoms, airway obstruction, and increased airway hyperresponsiveness in mid-childhood. At a median age of 21.7 years, 60 of these subjects (the index study group) and 50 healthy term control subjects were recruited to determine respiratory morbidity and spirometry. Measurements and Main Results: Respiratory symptom questionnaire, spirometry, and methacholine challenge test. The index study group had significantly more respiratory symptoms (16 of 60) than did control subjects (4 of 50) (odds ratio, 4.2; 95% confidence interval, 1.3 to 13.5; P = 0.01), but no significant difference in measured spirometry. Specifically, in the index study group and control subjects, the mean z scores (95% confidence interval of the group difference) for the FEV1 were –0.60 and –0.58 (–0.44 to 0.49), respectively (P = 0.92); for the forced mid-expiratory flow they were –1.02 and –0.86 (–0.33 to 0.64), respectively (P = 0.52); and for the FVC they were –0.29 and –0.33 (–0.46 to 0.38), respectively (P = 0.85). Ex-preterm adults did not show evidence of increased airway hyperresponsiveness compared with control subjects, 23 and 19%, respectively (P = 0.89). Conclusions: There are still excess respiratory symptoms 21 years after preterm birth. Reassuringly, this longitudinal study did not show evidence of persistent airway obstruction or airway hyperresponsiveness in ex-preterm adults
ISSN: 1073-449X
Type: Article
Description: This paper was published as American Journal of Respiratory and Critical Care Medicine, 2008, 178 (1), pp. 74-80. It is available from Doi: 10.1164/rccm.200705-701OC
Metadata only entry
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

Files in This Item:
There are no files associated with this item.

Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.