Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/9499
Title: Applications of accelerator mass spectrometry for pharmacological and toxicological research
Authors: Brown, Karen
Tompkins, Elaine M.
White, Ian N.H.
First Published: 29-Jul-2005
Publisher: John Wiley & Sons
Citation: Mass Spectrometry Reviews, 2006, 25 (1), pp. 127-145.
Abstract: The technique of accelerator mass spectrometry (AMS), known for radiocarbon dating of archeological specimens, has revolutionized high-sensitivity isotope detection in pharmacology and toxicology by allowing the direct determination of the amount of isotope in a sample rather than measuring its decay. It can quantify many isotopes, including 26Al, 14C, 41Ca, and 3H with detection down to attomole (10−18) amounts. Pharmacokinetic data in humans have been achieved with ultra-low levels of radiolabel. One of the most exciting biomedical applications of AMS with 14C-labeled potential carcinogens is the detection of modified proteins or DNA in tissues. The relationship between low-level exposure and covalent binding of genotoxic chemicals has been compared in rodents and humans. Such compounds include heterocyclic amines, benzene, and tamoxifen. Other applications range from measuring the absorption of 26Al to monitoring 41Ca turnover in bone. In epoxy-embedded tissue sections, high-resolution imaging of 14C label in cells is possible. The uses of AMS are becoming more widespread with the availability of instrumentation dedicated to the analysis of biomedical samples.
ISSN: 0277-7037
Links: http://dx.doi.org/10.1002/mas.20059
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2787
http://hdl.handle.net/2381/9499
Type: Article
Description: This paper was published as Mass Spectrometry Reviews, 2006, 25 (1), pp. 127-145. It is available from http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2787. DOI: 10.1002/mas.20059
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Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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