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First PublishedTitleAuthor(s)Type
21-Mar-2008Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.Giorgini, Flaviano; Möller, T; Kwan, W; Zwilling, D; Wacker, JL; Hong, S; Tsai, LC; Cheah, CS; Schwarcz, R; Guidetti, P; Muchowski, PJJournal Article
15-Jul-2009Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease.Wacker, Jennifer L.; Huang, Shao-Yi; Steele, Andrew D.; Aron, Rebecca; Lotz, Gregor P.; Nguyen,QuangVu; Giorgini, Flaviano; Roberson, Erik D.; Lindquist, Susan; Masliah, Eliezer; Muchowski, Paul J.Journal Article
2009Exploiting yeast genetics to inform therapeutic strategies for Huntington's disease.Giorgini, Flaviano; Muchowski, PJJournal Article
28-Feb-2005Connecting the dots in Huntington's disease with protein interaction networksGiorgini, Flaviano; Muchowski, Paul J.Journal Article
Mar-2006Yeast as a drug discovery platform in Huntington's and Parkinson's diseases.Outeiro, TF; Giorgini, FlavianoJournal Article
10-Jun-2011Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.Zwilling, D; Huang, SY; Sathyasaikumar, KV; Notarangelo, FM; Guidetti, P; Wu, HQ; Lee, J; Truong, J; Andrews-Zwilling, Y; Hsieh, EW; Louie, JY; Wu, T; Scearce-Levie, K; Patrick, C; Adame, A; Giorgini, Flaviano; Moussaoui, S; Laue, G; Rassoulpour, A; Flik, G; Huang, Y; Muchowski, JM; Masliah, E; Schwarcz, R; Muchowski, PJJournal Article
7-Jun-2011The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease.Campesan, S; Green, EW; Breda, C; Sathyasaikumar, KV; Muchowski, PJ; Schwarcz, R; Kyriacou, CP; Giorgini, FlavianoJournal Article
Feb-2011Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease.Richards, P; Didszun, C; Campesan, S; Simpson, A; Horley, B; Young, KW; Glynn, P; Cain, K; Kyriacou, CP; Giorgini, Flaviano; Nicotera, PJournal Article
10-Apr-2013Structural basis of kynurenine 3-monooxygenase inhibitionAmaral, Marta; Levy, Colin; Heyes, Derren J.; Lafite, Pierre; Outeiro, Tiago F.; Giorgini, Flaviano; Leys, David; Scrutton, Nigel S.Journal Article