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Title: Breast cancer chemoprevention: risk-benefit effects of the antioestrogen tamoxifen
Authors: Brown, Karen
First Published: Sep-2002
Publisher: Ashley Publications
Citation: Expert Opinion on Drug Safety, 2002, 1 (3), pp. 253-267.
Abstract: The anti-oestrogen tamoxifen, which is widely used as adjuvant therapy for breast cancer, is undergoing evaluation as a chemopreventive agent in women at increased risk of developing this disease. Recent results from the National Surgical Adjuvant Breast and Bowel Project (NSABP) P-1 prevention trial show a 49% reduction in breast cancer incidence in healthy, high-risk women. However, tamoxifen treatment has the serious side effect of increasing the incidence of endometrial cancer in women and long-term administration of tamoxifen causes hepatic tumours in rats. These liver tumours are induced via a genotoxic mechanism, but the mechanisms responsible for endometrial cancer in women are not yet known and are a focus of much debate. This review describes the findings from the chemoprevention trials and problems associated with the use of tamoxifen in this setting. The mechanism of carcinogenesis in rat liver is explained in detail and compared to the situation in humans, with a view to assessing the risks associated with tamoxifen therapy and predicting whether other anti-oestrogens might be safer alternatives.
DOI Link: 10.1517/14740338.1.3.253
ISSN: 1474-0338
Type: Article
Rights: This paper was published as Expert Opinion on Drug Safety, 2002, 1 (3), pp. 253-267. It is available from DOI: 10.1517/14740338.1.3.253
Description: Metadata only entry
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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